Mormino et al., 2017 analyzed rates of change in PACC scores in individuals who were amyloid positive/negative, and APOE-ε4 positive/negative, and found that, in a sample with a mean age of ~74, the average annual change in PACC for APOE-ε4 carriers was -.043, and APOE status was not a significant predictor of cognitive decline when accounting for amyloid positivity. Here, APOE is linked to Mental deterioration.