Notably, expression of CANX was found to be increased in the same CNS region of Alzheimer's disease cases suggesting a specific role of this gene in frontal cortex.9 Notably, although most of the changes were detected in frontal cortex, HERPUD1 and DNAJC3 were also significantly up‐regulated in temporal cortex of FTLD cases (Figure 4D, Figure S4). This evidence concerns the gene HERPUD1 and early-onset autosomal dominant Alzheimer disease.