PDIA4 and amyotrophic lateral sclerosis: In agreement with these results, ER stress pathways have been demonstrated to be activated in iPSC‐derived motor neurons, obtained from patients affected by ALS55 and in motor neurons of SOD1 transgenic mice from the early stages of ALS pathogenesis.8, 47 The expression of DNAJC10, HSPA5, PDIA6, PDIA4, DNAJA1 and DNAJB1 strongly correlated to ALS compared to control group indicating that these genes are somehow linked to the disease (Figure S8).