In particular, related pathological features are evident in advanced disease stages, when TDP‐43 pathology and cortical tissue changes of FTLD and ALS can be similarly abundant due to more profound degenerative changes.4, 5 The accumulation of TDP‐43+ve inclusions in these disorders is suggestive of defects in protein homeostasis (proteostasis). Here, TARDBP is linked to amyotrophic lateral sclerosis.