In agreement, several studies have demonstrated the role of protein quality control in spinal motor neurons.35, 36, 55 Moreover, in motor cortex, the oligodendrocyte‐associated signalling network comprising XBP1‐PDIA3 is supported by evidences that showed that gene therapy employed to deliver active XBP1 (XBP1s) into ALS mouse models had a significant impact on motor recovery after spinal cord injury, which was associated with enhanced oligodendrocyte survival.59 This evidence concerns the gene PDIA3 and amyotrophic lateral sclerosis.