DKK1 and Stroke: As regards the relationship between circulating DKK‐1 levels and disease severity of acute brain injury, only the two study has been done, in which no correlation of DKK‐1 levels was found with stroke severity (reflected by the National Institutes of Health Stroke Scale) in human acute ischemic stroke (He et al., 2016; Seifert‐Held et al., 2011).