Also, DKK‐1 levels in rat brain tissue were obviously enhanced early after intracerebral hemorrhage; inhibition of DKK‐1 could markedly ameliorated blood–brain barrier disruption and brain edema, lessened neurological deficits, increased the transcription of Wnt‐1 mRNA, and upregulated the expression of tight junction protein zonula occludens‐1 (Li et al., 2017). The gene discussed is DKK1; the disease is intracerebral hemorrhage.