DKK1 and ischemic stroke: To date, there were two clinical investigations assessing the association of DKK‐1 with ischemic stroke prognosis, and no significant associations were revealed (He et al., 2016; Seifert‐Held et al., 2011), because both studies are underpowered because of small sample sizes (<100) and short follow‐up time (3 months) (He et al., 2016; Seifert‐Held et al., 2011).