Accordingly, combined blockade of ETA and ETB receptors improves cardiopulmonary function in sheep with endotoxemia (42), improves survival in a mouse model of polymicrobial sepsis (43), maintains renal and cardiac functions in neonatal piglets with endotoxic shock (44), and improves tissue perfusion in pigs with endotoxemia (45, 46). This evidence concerns the gene EDNRA and Sepsis.