EDNRA and serum lipopolysaccharide activity: Accordingly, combined blockade of ETA and ETB receptors improves cardiopulmonary function in sheep with endotoxemia (42), improves survival in a mouse model of polymicrobial sepsis (43), maintains renal and cardiac functions in neonatal piglets with endotoxic shock (44), and improves tissue perfusion in pigs with endotoxemia (45, 46).