IL33 and asthma: Cells carrying the asthma risk haplotype (Ala433/Gln501/Thr549/Leu551) tagged by the Signal D SNP rs10192157 (CC) demonstrated a 2.9-fold induction at the highest dose of IL-33 (50 ng/mL) in this cell system, which was significantly higher than the modest activity observed for the asthma protective TIR domain haplotype protein (Thr433/Arg501/Ile549/Ser551) (1.3-fold) (Figure 6B).