We did not observe significant associations with lung function (FEV1 and FEV1/forced vital capacity [FVC]) in Lifelines and Manchester Asthma and Allergy Study (MAAS), nor with blood eosinophils, childhood onset asthma, total IgE levels, or lung function ratio (FEV1/FVC) in GASP/DAG. The gene discussed is IGHE; the disease is asthma.