Importantly, our data extend this work by offering a comprehensive analysis of all IL1RL1 transcripts (total, membrane, and soluble IL1RL1 encoding mRNA) and extends the recently suggested concept that asthma risk alleles essentially lead to a decrease in soluble IL1RL1, and this lack of decoy receptor diminishes the ability to mitigate the effects of IL-33 (36). This evidence concerns the gene IL33 and asthma.