IL1RL1 and asthma: The 3 tagging SNPs for the associated signals presented in this manuscript (Signal A: rs12474258, minor allele frequency [MAF]: 0.40, Asthma (T) OR: 1.20, FDR: 0.049, blood eosinophils (T) β: 0.03, FDR: 0.017; Signal B: rs4142132, MAF = 0.49, FEV1 (A) β: –0.07, FDR: 0.029; and Signal C: rs72825929, MAF = 0.10, Severe Asthma (A) χ2 statistic: 16.4, FDR: 0.035) span the IL1RL1 region (Figure 2) and demonstrate association with severe, eosinophilic asthma subtypes (Table 1).