IL1RL1 and asthma: In HBECs, as opposed to no effect in whole lung tissue, the asthma risk (T) allele for Signal A (tagged by rs995514) also associated with elevated blood eosinophil levels, resulted in a lower levels of soluble IL1RL1 protein, but had no effect on mRNA isoforms (Figure 3F and Supplemental Figures 3 and 4).