PDK4 and cancer: Conversely, in cancer cells that have undergone tumor progression via epithelial–mesenchymal transition (EMT), a low PDK4‐mediated metabolic shift from glycolysis to OXPHOS was reported, and knockdown of PDK4 was sufficient to induce EMT in human non‐small‐cell lung cancer (NSCLC) cell lines (Sun et al, 2014).