PTEN and posterior cortical atrophy: We used a previously established genetic PCa mouse model (Alonzi et al, 2001; Suzuki et al, 2001; Wu et al, 2001; Pencik et al, 2015) with conditional loss of either Pten (referred to as Ptenpc−/−) or concomitant loss of Pten and Stat3 (PtenStat3pc−/−) in the prostate epithelium.