BCR and metastatic neoplasm: PDK4 was a significant predictor of BCR both in primary tumors (univariate Cox PH model: beta: −0.758, HR: 0.469, P‐value: 0.001, Fig 6C) and in primary and metastatic tumors combined (beta: −0.981, HR: 0.375, adj P‐value: 2.25e‐05, Fig 6D, Table EV5).