For example, although hypoxic insult results in cytochrome C release from glioma cells, apoptosis inhibition using X‐linked inhibitor of apoptosis protein (XIAP) or caspase inhibitors fails to protect cells from hypoxic cell death (Steinbach, Wolburg, Klumpp, Probst, & Weller, 2003). This evidence concerns the gene CYCS and central nervous system cancer.