AP1G1 and Alzheimer disease: Since decreased levels of AP‐2α, but not the AP‐1γ1, were detected in iPSC‐derived neurons from patients with late‐onset AD (Figs 5A and B, and EV5A), we next asked whether increased amyloidogenic processing of APP in neurons lacking AP‐2 is relevant for AD‐associated synaptic pathology.