HSPB8 and amyotrophic lateral sclerosis: Moreover, it was recently demonstrated that some patients with HSPB1 and HSPB8 mutations may have rare forms of ALS or distal myopathy, respectively, further supporting the genetic and clinical heterogeneity (Dierick et al. 2007; Capponi et al. 2016; Ghaoui et al. 2016; Echaniz-Laguna et al. 2017b).