SOD1 and amyotrophic lateral sclerosis: Both HSPB1 and HSPB8 levels are upregulated in the muscle and/or surviving motor neurons in the spinal cord of transgenic G93A-SOD1 mice, as well as in the spinal cord of ALS patients (Vleminckx et al. 2002; Maatkamp et al. 2004; Krishnan et al. 2008; Anagnostou et al. 2010; Crippa et al. 2010; Crippa et al. 2013).