MAPT and tauopathy: Both HSPB1 and HSPB5 were shown to colocalize with tau fibrils in tauopathy brains and the amount of HSPB1 and HSPB5 was shown to correlate inversely with the levels of granular tau (Nemes et al. 2004; Sahara et al. 2007; Bjorkdahl et al. 2008).