In line with this, in the exon-1 fragment mouse model R6/2 for Huntington’s disease, a downregulation of chaperones including HSPB5 was observed (Zabel et al. 2002; Hay et al. 2004), which was also confirmed in a different mouse model for HTT (BACHD) (Oliveira et al. 2016; Wood et al. 2019). This evidence concerns the gene CRYAB and juvenile Huntington disease.