HSPB8 and amyotrophic lateral sclerosis: Similarly, overexpression of human HSPB8 in neuronal cell models for ALS also protected against aggregation seeding by TDP-25, TDP-35, and TDP-43 (Crippa et al. 2010; Crippa et al. 2016a; Crippa et al. 2016b; Cicardi et al. 2018).