Similarly, a partially compromised H-1-2 anti-tumor effect by AGR2 re-expression was also observed in vivo: ectopic introduction of AGR2 could restore the xenograft tumor growth (Figure 7A), and the weight of xenograft tumor at the endpoint was increased by re-expression of AGR2 in H-1-2-treated mice (Figure 7B), but not to control levels in both cases. Here, AGR2 is linked to neoplasm.