Importantly, an elevated level of AGR2 in pancreatic cancer tissues was verified using immunohistochemistry, cDNA, and tissue microarrays,22,23 while downregulation of AGR2 led to cell apoptosis and attenuated chemotherapy resistance of pancreatic cancer cells through the extracellular signal-regulated kinase (ERK)/AKT axis.24 This evidence concerns the gene AKT1 and pancreatic neoplasm.