CDC42 and cancer: However, in this study, oncogenic Dbs demonstrated increased Rho activation, and thus, even though Rho activity may not be relevant for the demonstrated Rac/Cdc42 mediated breast cancer cell migration via downstream activation of focal adhesion kinase/p130Crk associated substrate, the enhanced Rho activity in oncogenic Dbs expressing breast cancer cells may still contribute to other cancer promoting signaling pathways in cancer (Liu et al., 2009).