The pivotal role of Rac and Cdc42 in multiple cancers has been extensively reviewed by us and others (Pai et al., 2010; Mack et al., 2011; Stengel and Zheng, 2011; Wertheimer et al., 2012; Bid et al., 2013; Kazanietz and Caloca, 2017; Casado-Medrano et al., 2018; Maldonado and Dharmawardhane, 2018; De et al., 2019). This evidence concerns the gene CDC42 and cancer.