AKT1 and esophageal squamous cell carcinoma: Use of the Vav/Rac inhibitor EHop-016 was shown to overcome cisplatin resistance in esophageal squamous cell carcinoma in vitro and in vivo and by decreasing Akt/FOXO3a signaling and glycolysis (Schmit et al., 2019; Zeng et al., 2019), further validating its therapeutic applicability.