RAC1 and glioblastoma: DOCKs are activated by oncogenic RTKs, where in glioblastoma, the oncogenic epidermal growth factor receptor (EGFRvIII) and platelet derived growth factor receptor (PDGFR) induced Src-mediated tyrosine phosphorylation of DOCK1 to activate Rac1 and promote cell migration and invasion (Feng et al., 2011, 2012).