However, in this study, oncogenic Dbs demonstrated increased Rho activation, and thus, even though Rho activity may not be relevant for the demonstrated Rac/Cdc42 mediated breast cancer cell migration via downstream activation of focal adhesion kinase/p130Crk associated substrate, the enhanced Rho activity in oncogenic Dbs expressing breast cancer cells may still contribute to other cancer promoting signaling pathways in cancer (Liu et al., 2009). This evidence concerns the gene RHO and breast cancer.