VAV1 and cancer: However, studies have detected Vav1 expression in several types of cancer cells and tumor tissue, including neuroblastoma, ovarian, lung, pancreatic, head and neck, gastric, endometrial, cervical, and colorectal cancer, metastatic melanoma, and B-cell chronic lymphocytic leukemia (Cook et al., 2014; Farago et al., 2020) (Table 1).