ITSN1 and lung carcinoma: Even though low expression of ITSN1 was recently correlated with higher grade in breast and lung cancer (Xie et al., 2019; Zhang and Zhang, 2019), A role for ITSN in neuroblastoma has been shown by a study where knockdown of ITSN decreased orthotopic neuroblastoma growth in mice (Harris et al., 2017).