Whereas in renal cell carcinoma, miR-486-5p is decreased by interacted with the CCL2 (C-C motif chemokine ligand 2) of tumor-related macrophages, and miR-486-5p restoration is capable of inhibiting cell proliferation and inducing cell apoptosis (He et al., 2019). Here, CCL2 is linked to hereditary clear cell renal cell carcinoma.