One study reported that high p63 expression is associated with a more aggressive phenotype and poor prognosis in oral squamous cell carcinoma (OSCC) (Lo Muzio et al., 2005), whereas other studies either showed that impaired p63 expression could be important in neoplastic transformation of OSCC (Foschini et al., 2004) or could not find any significant association between p63 protein expression and survival, recurrence, or metastasis in OSCC patients (Oliveira et al., 2007). Here, TP63 is linked to oral cavity squamous cell carcinoma.