BMP2K and acute lymphoblastic leukemia: In fact, we showed that BMP2K overexpression antagonized multiple chemotherapy compounds that were known to cause megakaryocyte differentiation (nocodazole and TPA) or apoptosis (etoposide) [14, 15, 18, 32] or use for therapy of ALL and AMKL (methotrexate) [16, 17].