In the current study, we observed actively replicating RV to trigger time point-dependent bimodal regulation of Nrf2 in the form of sharp Nrf2 induction from as early as 2 hpi (data not shown) and extending up to 3 hpi followed by gradual decline even below the level of the mock-infected control with increasing time points post infection. This evidence concerns the gene NFE2L2 and infection.