First, Kranendonk et al. [2] expressed that lower Akt phosphorylation in hepatocytes was related to monocyte chemoattractant protein-1 (MCP-1), IL-6, and macrophage migration inhibitory factor (MIF) concentrations in EVs that these factors might play a key role in obesity-induced insulin resistance [32]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.