The high lifetime risk of breast and ovarian cancers in BRCA1/2 carriers is crucial for counselling, intensive breast and ovarian screening (annual MRI commenced from the age of 25 with the additional annual mammography from the age of 30, 6-monthly ovarian cancer screening with transvaginal ultrasound, and Ca125 serum measure started at the age of 30), and risk-reducing surgery (bilateral salpingo-oophorectomy and bilateral risk-reducing mastectomy including skin-sparing and nipple-sparing mastectomy) [9, 10]. Here, BRCA1 is linked to ovarian cancer.