As reactive astrocytes in MS lesions display coordinated upregulation of receptors for inflammatory cytokines (IL1R, IL17R) and the lipid mediator S1P (S1P1 and S1P3) (7), we checked protein expression of these receptors on human iAstrocytes and observed strong positivity for all of them (Figures 1C,E), indicating that our in vitro human cell model mimics the phenotype of the reactive glia cell in the human pathological tissue and may be responsive to inflammatory mediators. This evidence concerns the gene S1PR3 and myeloid sarcoma.