The increase of anti-CD4 IgG in acute HIV infection may attribute to the increase of autoantigens, such as debris arise from massive CD4+ T-cell apoptosis, sCD4, or HIV protein binding CD4 complex (Lederman et al., 2011; Koppensteiner et al., 2012; Luo et al., 2017b). Here, CD4 is linked to HIV infectious disease.