In an animal model, plasma levels of autoreactive antibodies against CD4+ T cells, but not anti-CD4 autoantibodies, was associated with progressive decline of CD4+ T cells in simian immunodeficiency virus (SIV)-infected rhesus macaques; and this association was observed in non-SIV animal models with immune activation and autoimmunity (Kuwata et al., 2009). Here, CD4 is linked to Autoimmunity.