NFKB1 and metabolic dysfunction-associated steatotic liver disease: The main findings of our study are as follows: (1) the RAS is important for glucose metabolism and liver function, as well as significant liver metabolic disorder in ACE2-deficient mice; (2) liraglutide ameliorated NAFLD in mice, which was associated with enhanced fatty acid β-oxidation, as well as suppression of gluconeogenesis and inflammation in the liver associated with NF-κB activation, which was attenuated in ACE2KO mice; (3) in both the in vivo and in vitro NAFLD models, the hepatic local RAS was over-activated.