The renin-angiotensin system (RAS) is critical in the regulation of glycolipid metabolism and insulin sensitivity, which are closely related to metabolic syndromes [e.g., obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD)] (Marcus et al., 2013). This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.