More importantly, inhibition of the ACE/AngII/AT1R axis by AT1R inhibitors (Rosselli et al., 2009; Montez et al., 2012; Sansoe et al., 2019), gene knockout animal models (Jayasooriya et al., 2008), or activation of the ACE2/Ang1-7/Mas axis by exogenous Ang1-7 (Munoz et al., 2012; Feltenberger et al., 2013; Cao et al., 2016) in rodents can ameliorate NAFLD by suppressing liver lipogenesis, enhancing fatty acid oxidation, and inhibiting inflammation and gluconeogenesis. The gene discussed is ACE2; the disease is metabolic dysfunction-associated steatotic liver disease.