Autophagy was found to impair the sensitivity of HCC cells to linifanib-targeted therapy by the suppression of Akt/mTOR and Mek/Erk signaling pathways and CQ, HCQ, or 3-MA greatly augments the anti-HCC effect of linifanib (Pan et al., 2014). Here, MTOR is linked to hepatocellular carcinoma.