Examining the adult and aging human as well as rodent brain suggests Bcl11b to be involved in a number of neurodegenerative disorders like Alzheimer’s disease (AD) (Desplats et al., 2008; Choi et al., 2018; Dard et al., 2018; Llorens-Martin, 2018), Huntington’s disease (HD) (Desplats et al., 2008; Ahmed et al., 2015), schizophrenia (Whitton et al., 2016, 2018), and amyotrophic lateral sclerosis (ALS) (Chesi et al., 2013; Lennon et al., 2016). Here, BCL11B is linked to Huntington disease.