Further studies showed that the L417V mutation in the UBA domain, which reduced ubiquitin-binding activity, also suppressed caspase 8 activation and the co-localization with LC3 induced by cisplatin, which suggests that p62-mediated autophagy may participate in cisplatin resistance through caspase 8 regulation in ovarian cancer [33]. The gene discussed is CASP8; the disease is ovarian carcinoma.