In regards to HM-inhibited ERK phosphorylation, TLR4 blockade reduced the inhibitory effect of HM on ERK phosphorylation detected in colorectal adenocarcinoma HT29 (Fig. 7g) and mCRC SW620 (Fig. 7h), as compared to HM-inhibited ERK phosphorylation detected in both cells (Figs. 7g, h). Here, TLR4 is linked to colorectal adenocarcinoma.