TLR4 blockade using neutralizing anti-TLR4 antibody confirmed this induction of apoptosis in both colorectal cancer HT29 (Fig. 7e) and SW620 (Fig. 7f) cells and revealed to be enhanced by the presence of HM, as compared with untreated cells, the control (Figs. 7e, f). The gene discussed is TLR4; the disease is colorectal cancer.