SH2B3 and triple-negative breast carcinoma: Unexpectedly, we found that LNK were significantly upregulated (Fig. 1b, c) during TNBC cell lines (MDA-MB-468, MDA-MB-231, HCC1937, BT549), compared to those of non-triple negative breast cancer cell lines (MCF7, SKBR3, BT474), when the cells were cultivated to complete medium containing 10% FBS.