Our results suggest that the adaptor protein LNK acts as a positive signal transduction modulator in TNBC which is similar to the ovarian cancer, and it is in contrast to the findings in hematologic malignancies, We believe that our observations are novel and open a new area of inquiry for this important adaptor protein, which may be regarded as a new drug targets in the following studies. Here, SH2B3 is linked to ovarian carcinoma.