SH2B3 and hematologic disorder: LNK enhanced the p-AKT and p-MAPK pathways, improved cell adhesion, and moderated cell migration, and advanced the in vivo tumor growth in a murine xenograft model [26, 27], which is in contrast to the detection in hematologic malignancies, and acts as a positive signal transduction modulator in ovarian cancers [13, 14, 28, 29].