And research also shows that LNK mutations have recently been found in patients with myeloproliferative neoplasms (MPNs), early T cell acute lymphoblastic leukemia, Ph-like acute lymphoblastic leukemia, B-precursor acute lymphoblastic leukemia, and Down syndrome-related myeloid disorders [29, 31, 32, 34, 35]. This evidence concerns the gene SH2B3 and Down syndrome.