And research also shows that LNK mutations have recently been found in patients with myeloproliferative neoplasms (MPNs), early T cell acute lymphoblastic leukemia, Ph-like acute lymphoblastic leukemia, B-precursor acute lymphoblastic leukemia, and Down syndrome-related myeloid disorders [29, 31, 32, 34, 35]. The gene discussed is SH2B3; the disease is acute lymphoblastic leukemia.