The results showed that the MDA-MB-231 was forced silenced LNK, the number of breast cancer cells in the medium were reduced, and on the other hand, the MDA-MB-468 were forced expressing LNK, the number of breast cancer cells were significantly increased (Fig. 4c–e), which was consistent with the results of the colony formation assay, which furtherly confirmed that LNK can promote TNBC proliferation. The gene discussed is SH2B3; the disease is breast cancer.