Recent studies showed that LNK mutations have also been found in patients with myeloproliferative neoplasms (MPN) [20] and mainly mutated in hematopoietic malignancies including 3–5% of MPN samples, 10% of MPN evolved to acute myeloid leukemia, and 5% of early T cell leukemia [21]. This evidence concerns the gene SH2B3 and myeloproliferative disorder.