Significance were found in all 20 differentially-expressed KIFs regarding either OS, RFS or DMFS except for KIF22, while overexpression of 11 KIFs (KIF10, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF23, KIF2C, KIF4A, KIFC1) were found to be significantly related to worse outcomes regarding OS, RFS and DMFS, indicating that KIFs play important roles in breast cancer and hold the key to the prognosis of patients (Fig. 2a). Here, KIF22 is linked to breast carcinoma.