Several other genes pertaining to these networks may be dysregulated in synovial sarcoma, including LEF1, AXIN2, TCF7, and FZD homologues in the Wnt/β-catenin, HES1, and NOTCH1 in the Notch, as well as SMO and PTCH in the Sonic Hedgehog pathways [15, 36, 40, 41]. The gene discussed is HES1; the disease is synovial sarcoma.