MYC and Huntington disease: Considering that both HD and Myc knockdown caused a decrease in the number of germline cells at these stages, and that Myc expression was reduced in HD progeny prior to these stages, it is reasonable to conclude that overexpression of Myc overrides Myc downregulation in the HD germline prior to these stages, which would otherwise decrease the number of germline cells and consequently the germline-loss phenotype.