Furthermore, the levels of Myc-GFP and endogenous Myc mRNAs were significantly reduced in the germline cells of HD males at embryonic stage 17 (Supplementary Fig. 3a–e, g), although we could not detect these mRNAs in the female germline cells at the mid-second instar, presumably because it was difficult for the probes to permeate the gonads. The gene discussed is MYC; the disease is Huntington disease.