Similar results were observed in other in vitro models of pediatrics and CNS tumors (in e.g rhabdomyosarcoma, glioblastoma, leukemia and HGNET-BCOR tumor)9,10,12,13,16, but the exact connection between tumor response to ATO and TP53 mutational status has not been elucidated so far. Here, TP53 is linked to leukemia.