Similar results were observed in other in vitro models of pediatrics and CNS tumors (in e.g rhabdomyosarcoma, glioblastoma, leukemia and HGNET-BCOR tumor)9,10,12,13,16, but the exact connection between tumor response to ATO and TP53 mutational status has not been elucidated so far. This evidence concerns the gene TP53 and central nervous system neoplasm.