In summary, we herein examined subcellular EGFR interactomes, analyzed the putative functions of EGFR at these subcellular locations, and report that a nuclear EGFR-interacting protein selected for further study, hnRNP A3, modulates nuclear EGFR accumulation and tumor growth in NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.