EIF2AK3 and Wolcott-Rallison syndrome: To the best of our knowledge three patients carried a novel mutation in EIF2AK3: the compound heterozygous mutation c.1474 C > T, p.(Arg492*);  c.2081 C > G, p.(Ser694*) was detected in a German female with WRS of Syrian-origin, the homozygous mutation c.1A > G, p.Met?