Although comparison of our results with those obtained from the study of MIF over-expressing transgenic mice (MIFTG) [12, 13] lead us to speculate that MIF is involved, a relationship between miR-451 and MIF within the context of BPD can only be suggested, as modulation of this signaling pathway by other molecules is probably playing a role. The gene discussed is MIF; the disease is bronchopulmonary dysplasia.