Studies published by our group utilizing murine models of neonatal hyperoxia induced lung injury (HALI) and BPD have strongly suggested that the protective effect of MIF is mediated through regulation of the Ang-Tie2 axis [12, 13] and promotion of angiogenesis through upregulation of VEGF-A [37, 38]. The gene discussed is MIF; the disease is bronchopulmonary dysplasia.