In humans, IBD has an impact on AA metabolism, showing increased levels of isoleucine (and its first degradation product 3-methyl-2-oxovalerate), MET, LYS, GLY, ARG, and PRO and decreased levels of VAL, TYR, and SER as compared to the control cohort [16, 19]. The gene discussed is LINC01546; the disease is inflammatory bowel disease.