The pooled result indicated that increased SNHG6 expression was associated with a poor RFS in hepatocellular carcinoma and colorectal cancer (HR = 3.27, 95% CI: 1.42–5.12, p < 0.001; I2 = 0.0%, p = 0.93). This evidence concerns the gene SNHG6 and hepatocellular carcinoma.