Moreover, in colorectal cancer, SNHG6 functioned as an oncogene to interact with UPF1 to activate TGF-β/Smad signaling pathway, promotes proliferation, invasion, and migration [27], and our results also suggested that evaluated SNHG6 significantly related to unfavorable prognosis and advanced clinicopathological characteristics for patients with colorectal cancer. The gene discussed is UPF1; the disease is colorectal cancer.