Though the families included in this study had not been systematically screened for hereditary breast and ovarian cancer, our data support a role for hereditary breast and pancreatic cancer in FCCTX, and application of broader diagnostic genetic panels that also cover the BRCA2 gene may, based on our data, have a potential to identify disease-predisposing mutations in some FCCTX families. The gene discussed is BRCA2; the disease is pancreatic neoplasm.