The increased risks of breast cancer with IRRs 1.5–1.7 in the age group 30–69 years and pancreatic cancer with an IRR of 2.2 after age 70 support the suggestion of disease-predisposing variants in BRCA2, causing the observed malignancies in a small subset of FCCTX families [10]. This evidence concerns the gene BRCA2 and breast cancer.