The antigen-processing machinery (APM) is composed of the proteasome, where exogenous and tumour antigens are degraded into peptides; transporters associated with antigen presentation (TAPs), which are responsible for the translocation of peptide precursors; endoplasmic reticulum aminopeptidases (ERAPs), which trim the peptides to fit major histocompatibility complex (MHC) molecules; and MHC proteins, which present antigen peptides on the cell surface [1, 2]. This evidence concerns the gene HLA-C and neoplasm.