In 2014, Stratikos et al. and Alvarez-Navarro et al. reported that rs26653, which is a non-synonymous polymorphism resulting in a P127R substitution, may be associated with ERAP expression [18, 49], and this substitution may also affect the enzymatic activity of ERAP1 in the editing of tumour antigen peptides. The gene discussed is ERAP1; the disease is neoplasm.