RORα-deficient mice harboring a natural deletion in the ligand-binding domain exhibit cerebellar ataxia, a phenotype also observed in Staggerer (sg/sg) mutant mice [15], which express mutated RORα and present with vascular dysfunction, dyslipidemia, excessive inflammation, immune abnormalities, and diet-induced atherosclerosis [16–18]. The gene discussed is RORA; the disease is cerebellar ataxia.