PLCB1 and cancer: Nevertheless, the reduced abundance of genus Paeniclostridium and genus Enterococcus in cancer tissues also exhibited significant associations with the expression difference of PLCB1 (r = 0.995, p-value = 0.01, df = 2; Table 2) and IGSF9, respectively (r = − 0.997, p-value = 0.003, df = 2; Table 2).