Several NFE2L2 activators such as sulforaphane, bardoxolone methyl (RTA402), omaveloxolone (RTA 408), and dimethyl fumarate (DMF) have been developed in the USA; especially, bardoxolone methyl are developed in phase III for diabetic nephropathy, which is stronger activity than other NFE2L2 activators [11]. Here, NFE2L2 is linked to diabetic kidney disease.