Some examples are Iseganan (withdrawn after phase III) intended for the treatment of oral mucositis117,123 and Omiganan (withdrawn after phase III), a topical gel for prevention of catheter infections, acne and rosacea.122,124 These failures have spurred the development of encapsulation strategies of AMPs into different delivery systems, such as nanoparticles and liposomes, to enhance their stability and half-life. The gene discussed is ADSL; the disease is acne.