DEFB1 and urinary tract infection: For instance, S. aureus together with an aureolysin metalloprotease could degrade LL-37 AMP by cleaving C-terminus bonds of the peptide and in turn contributing to resistance.95 ZapA metalloprotease could inhibit bacterial activity of LL-37 and hBD-1 against Proteus mirabilis, responsible for urinary tract infections, by at least 7- and 30-fold, respectively.