CD274 and small cell lung carcinoma: In LS-SCLC, combined modality therapy with concurrent chemotherapy and thoracic radiation therapy have long been demonstrated to improve survival.2 Multidisciplinary care has also been proven to play a crucial role in ES-SCLC where cytotoxic chemotherapy,3 thoracic radiotherapy,4 and PD-1/PD-L1–directed immunotherapy provide a survival benefit.5