To summarize, we showed the up‐regulation of MIR4435‐2HG in GBM tissues and cell lines and uncovered that MIR‐4435‐2HG promoted GBM cell proliferation and invasion via regulating TGFBR2 expression by sponging miR‐1224‐5p. The gene discussed is TGFBR2; the disease is glioblastoma.