As a negative regulator, Nur77 is activated by cytosporone B (CsnB) and suppresses ET-1 expression by decreasing the lipopolysaccharide (LPS)-induced phosphorylation of NF-κΒ p65 and p38 MAPK, which relieved lung injury in a mouse model of ARDS [54]. The gene discussed is NR4A1; the disease is acute respiratory distress syndrome.