Together, our study indicated that DHL has the potential to inhibit human laryngeal carcinoma via activating mitochondrial apoptosis pathway by inhibiting PI3K/Akt/Bad signalling pathway and stimulating endoplasmic reticulum stress‐mediated apoptosis pathway, providing a strategy for the treatment of human laryngeal carcinoma. The gene discussed is AKT1; the disease is laryngeal carcinoma.