Mechanistically, DHL inhibits the proliferation of laryngeal carcinoma cells by controlling the process of cell cycle, meanwhile DHL dose‐dependently induced apoptosis of laryngeal carcinoma cells via activating mitochondrial apoptosis pathway by inhibiting PI3K/Akt/Bad signalling pathway and stimulates endoplasmic reticulum stress‐mediated apoptosis. This evidence concerns the gene AKT1 and laryngeal carcinoma.