As a negative regulator of TGF‐β/BMP and Wnt/β catenin pathways (Asadipooya & Weinstock, 2019), sclerostin is involved not only in bone remodeling, but also (through TGF‐β and Wnt signaling) might play a role in the adverse cardiac remodeling, particularly in the progression of heart failure (Guo & Dong, 2014; Hermans & Blankesteijn, 2015). This evidence concerns the gene TGFB1 and heart failure.