The importance of BMP4 signaling in the development of cardiac hypertrophy was demonstrated in studies showing that pressure overload‐induced left ventricular hypertrophy (Sun et al., 2013) and cardiac ischemia–reperfusion injury (Pachori et al., 2010) were attenuated in BMP4‐deficient animals or when BMP inhibitors were used. This evidence concerns the gene BMP4 and ischemia.