In light of the different methylation levels in the intrahepatic and extrahepatic cholangiocarcinomas, the clinicopathological findings and favorable prognostic outcome provide the possibility of the multicentric developments in the intrahepatic and extrahepatic biliary tree due to the past exposure to DCP and DCM as in the previous reports [5, 11]. This evidence concerns the gene ACE and familial dilated cardiomyopathy.