Therefore, we investigated the combination of [TIMP-2] × [IGFBP7] and PCT for AKI prediction with the hypothesis that the addition of an AKI biomarker with a sepsis biomarker may lead to early identification of patients with sepsis-induced AKI in order to direct preventive or proactive strategies and preserve renal function. The gene discussed is IGFBP7; the disease is Sepsis.