Tauopathies consist of neurodegenerative diseases including, among others, Alzheimer’s disease (AD), frontotemporal dementia and atypical parkinsonian syndromes such as progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), with the connective characteristic of misfolded and accumulated tau protein in different parts of the brain [1, 2]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.