RNA‐seq data have shown that 12 subtypes of tumors have an approximately 2‐fold increase in OGR1 expression.12, 13 In addition to cancer cells, OGR1 may also be expressed in a variety of stromal cells of the TME (tumor microenvironment), including T cells, macrophages, endothelia cells, and cancer‐associated fibroblasts. This evidence concerns the gene GPR68 and cancer.