This finding is in line with a previous report by K Sato and colleagues showing that intracellular GSH levels could be increased in Schwann cells using Epalrestat via the transcription regulation of Nrf2.27 As well as increasing GSH concentration, we also noticed that Epalrestat increased the overall activity of superoxide dismutase and catalase in the brain of Parkinson's afflicted mice (Figure 6G,H). This evidence concerns the gene CAT and Parkinson disease.