NFKB1 and Parkinson disease: Neuroinflammation is a common and prominent feature of PD and other neurodegenerative disorders.13 Activated microglia have been reported to mediate the neuroinflammation in PD.81 Activated microglial cells are an important source of superoxide and NO, which in turn contribute to oxidative and nitrosative stress in the brain.63 ROS are also known to activate the nuclear factor‐kappa‐B (NF‐κB), which in turn activates various pro‐inflammatory genes.56