Reserpine has long been used to induce Parkinson's‐like symptoms in rodents.57, 58, 59, 60 Reserpine depletes cellular monoamine content by inhibiting the vesicular transporter of monoamines (VMAT2) in the central nervous system.61, 62 In this study, we successfully induced the altered motor symptoms of Parkinson's disease upon injection of reserpine in Swiss Albino mice. The gene discussed is SLC18A2; the disease is Parkinson disease.